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KMID : 0861120060100010013
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Korean Journal of Oriental Preventive Medicine
2006 Volume.10 No. 1 p.13 ~ p.32
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The Effects of Astragali Radix on Cyclophosphamide-induced Leucopenia
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Chang Jae-Min
Ko Seong-Gyu
Shin Yong-Cheol
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Abstract
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In order to indentify the effect of Astragali Radix(A.R) on cyclophosphamide(C.Y) induced leukopenia, A.R. extracts(EAR) were treated to mice orally, and blood sampling was done by periods. For the in vivo experiments, mice were divided into 4 groups, which treated EAR before, or after C.Y injection, or both, or none. Rapid normalization in the peripheral blood count of WBC, neutrophils, lymphocytes, RBC, and platelets observed in every EAR treated group regardless of the treatment periods of EAR. These studies suggest that, A.R. premedication can be effective in protection of bone marrow suppression during anticancer therapy.
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KEYWORD
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Astragali Radix, leukopenia, lymphocytes, anticancer therapy
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